U - Intracellular trafficking, secretion, and vesicular transport
Stats
| COG definitions |
Organims | Proteins | Median Protein Length |
Genes |
|---|---|---|---|---|
| 202 | 2,289 | 135,769 | 343.0 | 195 |
| Organism | Protein | COG | Cat | Annotation |
|---|---|---|---|---|
| 2264 | 2306 | COG0201 | U | Preprotein translocase subunit SecY |
| 2035 | 2132 | COG0341 | U | Preprotein translocase subunit SecF |
| 2042 | 2209 | COG0342 | U | Preprotein translocase subunit SecD |
| 2188 | 2198 | COG0541 | U | Signal recognition particle GTPase Srp/Ffh |
| 2170 | 2175 | COG0552 | U | Signal recognition particle GTPase FtsY |
| 2030 | 2344 | COG0597 | M U | Lipoprotein signal peptidase |
| 289 | 654 | COG0630 | N U | Type IV secretion system ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI |
| 2058 | 2337 | COG0653 | U | Preprotein translocase subunit SecA |
| 1905 | 1910 | COG0658 | U | DNA uptake channel protein ComEC, N-terminal domain |
| 2103 | 3083 | COG0681 | U | Signal peptidase I |
| 1888 | 1891 | COG0690 | U | Preprotein translocase subunit SecE |
| 1556 | 4304 | COG0741 | M U | Soluble lytic murein transglycosylase or regulatory protein ( may contain LysM/invasin domain), , includes type III secretion system proteins IagB/IpgF/YsaH |
| 1795 | 2004 | COG0805 | U | Twin-arginine protein secretion pathway component TatC |
| 1385 | 4202 | COG0811 | U | Biopolymer transport protein ExbB/TolQ |
| 1470 | 3701 | COG0823 | U | Periplasmic component TolB of the Tol biopolymer transport system |
| 1353 | 4483 | COG0848 | U | Biopolymer transport protein ExbD |
| 103 | 103 | COG1096 | U | Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains |
| 115 | 116 | COG1097 | U | Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains |
| 1085 | 1294 | COG1157 | N U | Flagellar biosynthesis/Type III secretion system ATPase FliI/YscN/InvC/EscN, SctN family |
| 177 | 198 | COG1223 | U | Type VII secretion system ATPase EccA, AAA family |
| 1147 | 1238 | COG1272 | U | Progestin and AdipoQ receptors (PAQRs) homolog, hemolysin III family |
| 1430 | 1430 | COG1314 | U | Protein translocase subunit SecG |
| 898 | 1024 | COG1317 | N U | Flagellar biosynthesis/Type III secretion system stator protein FliH/YscL/OrgB/HrpE, SctL family |
| 153 | 156 | COG1325 | U | Exosome subunit, RNA binding protein with dsRBD fold |
| 1233 | 4617 | COG1357 | U | Type IVB secretion/DNA transfer system protein DotG/IcmE, contains pentapeptide repeats |
| 169 | 170 | COG1400 | U | Signal recognition particle subunit SEC65 |
| 865 | 1812 | COG1450 | N U | Type II/type III secretion systems/type IV pilus secretin GspD/PulD/PilQ/YscC/InvG/EscC/HrcC,GspD/ SctC family |
| 1370 | 2780 | COG1459 | N U | Type II secretion system/type IV pilus membrane platform protein GspF/PulF/PilC |
| 856 | 975 | COG1516 | N U | Flagellin-specific chaperone FliS |
| 1063 | 1164 | COG1766 | N U | Flagellar biosynthesis/type III secretion system M-ring protein FliF/YscJ |
| 1745 | 3199 | COG1826 | U | Twin-arginine protein secretion pathway components TatA, TatB, TatE |
| 170 | 172 | COG1855 | W U | Predicted ATPase, PilT family, contains N-terminal PIN domain |
| 1836 | 1856 | COG1862 | U | Protein translocase subunit YajC |
| 1090 | 1489 | COG1886 | N U | Flagellar biosynthesis/Type III secretion system protein FliN/YscQ/SpaO/HrcQ, SctQ family |
| 806 | 825 | COG1952 | U | Preprotein translocase subunit SecB |
| 1250 | 1350 | COG1989 | N U | Type II secretion system/type IV prepilin peptidase GspO/PulO/PilD |
| 119 | 121 | COG2123 | U | Exosome complex RNA-binding protein Rrp42, RNase PH superfamily |
| 1158 | 6624 | COG2165 | N U | Type II secretion system/type IV prepilin peptidase GspO/PulO/PilD |
| 330 | 763 | COG2229 | U | Signal recognition particle receptor subunit beta, a GTPase |
| 532 | 559 | COG2257 | U | Type III secretion system substrate exporter, FlhB-like |
| 1400 | 1925 | COG2333 | U | DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily |
| 166 | 166 | COG2443 | U | Preprotein translocase subunit Sss1 |
| 1361 | 3276 | COG2804 | N U | Type II secretion system/type IV pilus assembly ATPase GspE/PulE/PilB |
| 1032 | 1676 | COG2805 | N U | Type IV pilus retraction ATPase PilT/PilU |
| 534 | 1056 | COG2831 | U | Two-partner (type Vb) secretion system protein, HlyB/FhaC/ShlB/HecB family |
| 1115 | 1390 | COG2911 | U | Autotransporter translocation and assembly protein TamB |
| 292 | 526 | COG2948 | U | Type IV secretion/DNA transfer system protein VirB10/TraF |
| 274 | 316 | COG3031 | N U | Type II secretion system/type IV pili GspC/PulC/PilP protein, contains PDZ domain |
| 313 | 317 | COG3114 | U | Heme exporter protein D |
| 218 | 233 | COG3126 | U | Type III secretion system pilotin YscW/InvH/MxiM, SctG/YbaY family |
| 264 | 276 | COG3149 | U | Type II secretory pathway, component PulM |
| 507 | 589 | COG3156 | U | Type II secretory pathway, component PulK |
| 351 | 730 | COG3157 | U | Type VI secretion system tube protein TssD/Hcp |
| 635 | 690 | COG3166 | N U | Type II secretion system/type IV pilus alignment protein GspM/PulM/PilN |
| 546 | 564 | COG3167 | N U | Type II secretion system/type IV pilus alignment protein PilO |
| 378 | 380 | COG3168 | N U | Type IV pilus assembly protein PilP |
| 464 | 607 | COG3170 | N U | Type IV pilus assembly protein FimV |
| 465 | 1513 | COG3210 | U | Large exoprotein involved in heme utilization or adhesion |
| 607 | 1188 | COG3267 | W U | Type II secretory pathway ATPase component GspA/ExeA/MshM |
| 154 | 187 | COG3271 | U | Predicted double-glycine leader peptidase, C39-like (CLD) domain |
| 283 | 294 | COG3297 | U | Type II secretory pathway, component PulL |
| 245 | 255 | COG3418 | N U | Flagellar biosynthesis/type III secretory pathway chaperone FlgN |
| 887 | 1677 | COG3451 | U | Type IV secretion system ATPase VirB4 |
| 337 | 472 | COG3455 | U | Type VI secretion system membrane component TssL/VasF/DotU |
| 271 | 328 | COG3456 | U | Type VI secretion system component, contains N-terminal FHA domain |
| 158 | 515 | COG3468 | M U | Autotransporter adhesin AidA |
| 505 | 1461 | COG3501 | U X | Type VI secretion system spike component VgrG, |
| 274 | 502 | COG3504 | U | Type IV secretion/DNA transfer system protein VirB9/TraO/TrbG/CagX |
| 959 | 1928 | COG3505 | U | Type IV secretion/DNA transfer system ATPase VirD4/TraG/TraD |
| 312 | 465 | COG3515 | U | Type VI secretion system cap component TssA/VasJ/EvfE, contains ImpA_N domain |
| 335 | 489 | COG3516 | U | Type VI secretion system sheath component TssB/VipA/Hcp2 |
| 332 | 569 | COG3517 | U | Type VI secretion system sheath component TssC/VipB |
| 328 | 436 | COG3518 | U | Type VI secretion system baseplate component TssE |
| 333 | 472 | COG3519 | U | Type VI secretion system baseplate component TssF/VasA |
| 330 | 447 | COG3520 | U | Type VI secretion system baseplate component TssG |
| 227 | 304 | COG3521 | U | Type VI secretion system outer membrane lipoprotein TssJ/VasD/EvfM/SciN/Cytochrome oxidase assembly protein CtaK |
| 342 | 477 | COG3522 | U | Type VI secretion system baseplate component TssK/ImpJ/VasE |
| 328 | 491 | COG3523 | U | Type VI secretion system membrane component TssM/ImcF/VasK |
| 217 | 293 | COG3559 | U | Putative exporter of oligosaccharides and polyketide antibiotics DrrB/NodJ, ABC-2 family |
| 179 | 296 | COG3701 | U | Type IV secretion/DNA transfer system protein TrbF, VirB8/TrbF family |
| 128 | 161 | COG3702 | U | Type IV secretion system core protein VirB3 |
| 147 | 245 | COG3704 | U | Type IV secretion/DNA transfer system core protein VirB6, VirB6//TrbL family |
| 132 | 193 | COG3736 | U | Type IV secretion/DNA transfer system core protein VirB8 |
| 199 | 351 | COG3838 | U | Type IV secretion/DNA transfer system pilin VirB2/TrbC |
| 132 | 223 | COG3843 | U | Type IV secretion/DNA transfer system DNA endonuclease (relaxase) VirD2 |
| 176 | 271 | COG3846 | U | Type IV secretion/DNA transfer system protein TrbL, VirB6//TrbL family |
| 192 | 223 | COG3913 | T U | Type VI secretion system regulator TagF/ImpM/SciT |
| 251 | 333 | COG3926 | U | Type X secretion system component, combines lysozyme-like N-acetylmuramidase GH108 and peptidoglycan hydrolase domains |
| 82 | 98 | COG3946 | U | Type IV secretion/DNA transfer system protein VirJ |
| 148 | 148 | COG4023 | U | Preprotein translocase subunit SecG (Sec61beta) |
| 98 | 111 | COG4083 | U | Exosortase/Archaeosortase |
| 331 | 675 | COG4104 | U | Type VI secretion system tip component, contains N-terminal Pro-Ala-Ala-Arg (PAAR) domain |
| 133 | 138 | COG4455 | U | Type VI secretion system component TagJ/ImpE |
| 149 | 166 | COG4473 | U | Predicted ABC-type exoprotein transport system, permease component |
| 44 | 44 | COG4499 | U | ESX protein secretion system component YukC |
| 298 | 454 | COG4618 | U | ABC-type protease/lipase transport system, ATPase and permease components |
| 127 | 163 | COG4669 | U | Type III secretion system inner ring protein YscJ/PrgK/MxiJ/HrcJ, SctJ family |
| 103 | 203 | COG4743 | U | Membrane-anchored component of a predicted archaeal secretion system, DUF1616 family |
| 127 | 162 | COG4789 | U | Type III secretion system gate protein YscV/InvA/EscV/HrcV, SctV family |
| 124 | 157 | COG4790 | U | Type III secretion system protein YscR/SpaP/EscR/HrcR, SctR family |
| 118 | 147 | COG4791 | U | Type III secretion system protein YscT/SpaR/EscT/HrcT, SctT family |
| 44 | 50 | COG4792 | U | Type III secretion system protein YscU/SpaS/EscU/HrcU, SctU family |
| 108 | 133 | COG4794 | U | Type III secretion system protein YscS/SpaQ/EscS/HrcS, SctS family |
| 564 | 717 | COG4795 | U | Type II secretion system protein PulJ/XcpW |
| 575 | 651 | COG4796 | U | Type II secretion system/DNA uptake membrane channel ComE/HofQ |
| 611 | 1656 | COG4886 | U | Type III secretion system effector YopM, contains leucine-rich repeats |
| 498 | 681 | COG4959 | U | Type IV secretion/DNA transfer system protease TraF |
| 958 | 1246 | COG4972 | N U | Type II secretion system/type IV pilus alignment protein GspL/PulL/PilM |
| 73 | 74 | COG5036 | U P | SPX domain-containing protein involved in vacuolar polyphosphate accumulation |
| 12 | 12 | COG5153 | U | Putative lipase ATG15 (essential for vacuolar disintegration of autophagic bodies) |
| 157 | 253 | COG5268 | U | Type IV secretion/DNA transfer system protein TrbD, VirB3/TrbD family |
| 155 | 331 | COG5295 | W U | Type Vc autotransporter adhesin, Ata/Hia family |
| 62 | 63 | COG5407 | U | Preprotein translocase subunit Sec63 |
| 34 | 34 | COG5417 | U | ESX protein secretion system component YukD |
| 27 | 30 | COG5555 | U | Cytolysin, a secreted calcineurin-like phosphatase |
| 126 | 143 | COG5571 | U | Secreted esterase EstA, contains T5SS autotransporter beta-barrel domain |
| 19 | 25 | COG5599 | T U | Type III secretion system effector, protein-tyrosine-phosphatase YopH |
| 21 | 21 | COG5613 | U | Type III secretion system needle tip translocon YopB/SipB/EspD/SseC/AopB, SctE family |
| 244 | 249 | COG6001 | U | Type II secretion system protein GspN/PulN |
| 65 | 81 | COG6002 | U | Type II secretion system pilotin GspS/PulS/OutS/YacC |
| 11 | 12 | COG6003 | U | Type II secretion system pilotin AspS/EpsS |
| 319 | 446 | COG6004 | U | PilJ domain of type IV pilus chemoreceptor PilJ |
| 3 | 3 | COG6005 | U | Type IV pilus minor pilin PilY2 |
| 3 | 3 | COG6006 | U | Type IV pilus minor pilin PilX2 |
| 6 | 6 | COG6009 | U | Type III secretion system needle tip protein LcrV/PcrV/SipD/EscA, SctA family |
| 6 | 6 | COG6010 | U | Type III secretion system needle tip translocon YopD/SipC/EspA, SctB family |
| 84 | 95 | COG6011 | U | Type III secretion system inner ring protein YscD/PrgH/EscD/HrpQ, SctD family |
| 39 | 52 | COG6012 | U | Type III secretion system needle protein YscF/PrgI/MxiH/EscF/SsaG, SctF family |
| 45 | 48 | COG6013 | U | Type III secretion system inner rod protein YscI/LcrO/PrgJ/MxiI/HrpB, SctI family |
| 14 | 16 | COG6014 | U | Type III secretion system protein YscK/OrgA/HrpD, SctK family |
| 28 | 30 | COG6015 | U | Type III secretion system central stalk protein YscO/InvI, SctO family |
| 18 | 19 | COG6016 | U | Type III secretion system needle length ruler YscP/SsaP/HrpP, SctP family |
| 66 | 79 | COG6017 | U | Type III secretion system gate keeper YopN/LcrE/InvE/HrpJ, SctW family |
| 6 | 6 | COG6018 | U | Type III secretion system needle cochaperone protein YscG |
| 19 | 20 | COG6019 | U | Type III secretion system needle pore protein YscE/SsaE/EscE |
| 77 | 254 | COG6020 | U | Type III secretion system pore protein YscB, YscB/CesT family |
| 69 | 132 | COG6021 | U | Type III secretion system chaperone LcrH/SycD/CesD/SicA/SscA/SscB, contains TPR repeats |
| 14 | 14 | COG6022 | U | Type III secretion system regulator YscX |
| 23 | 25 | COG6023 | U | Type III secretion system chaperone SycN |
| 36 | 39 | COG6024 | U | Type III secretion system gate regulator TyeA, interacts with or fused to YopN/HrpJ/SctW |
| 8 | 8 | COG6025 | U | Type III secretion system effector, GTPase-activating protein YopE/SptP |
| 15 | 20 | COG6026 | U | Type III secretion system effector YopJ/YopP, protein Ser/Thr-acetyltransferase |
| 6 | 6 | COG6028 | U | Type III secretion system effector YscH/YopR |
| 36 | 54 | COG6029 | U | Type III secretion system effector YopT, cysteine protease C58 family |
| 3 | 6 | COG6030 | U | Type III secretion system effector LcrQ/YscM1/YscM2 |
| 100 | 119 | COG6031 | U | Type IV secretion system lytic transglycosylase VirB1 |
| 2 | 2 | COG6032 | U | Type IV secretion system pilus tip protein VirB5 |
| 4 | 4 | COG6033 | U | Type IV secretion system outer membrane lipoprotein VirB7/TraN |
| 29 | 31 | COG6034 | U | Type IVB secretion/DNA transfer system protein DotC/TraI |
| 28 | 30 | COG6035 | U | Type IVB secretion/DNA transfer system protein DotD |
| 13 | 30 | COG6036 | U | Type IVB secretion/DNA transfer system protein DotE/IcmC |
| 49 | 51 | COG6037 | U | Type IVB secretion/DNA transfer system protein DotF/IcmG |
| 29 | 33 | COG6038 | U | Type IVB secretion/DNA transfer system protein DotH/IcmK, contains pentapeptide repeats |
| 19 | 22 | COG6039 | U | Type IVB secretion/DNA transfer system protein DotN/IcmJ |
| 66 | 69 | COG6040 | U | Type VI secretion system-associated protein TagO/VasI/EvfG |
| 47 | 59 | COG6041 | U | Type VI secretion system-associated protein VasL/EvfB |
| 14 | 20 | COG6042 | U | TSS6-secreted immunity protein Tse6 of the Tse6-Tsi6 toxin-antitoxin module, |
| 11 | 17 | COG6043 | U | TSS6-secreted toxin Tsi6 of the Tse6-Tsi6 toxin-antitoxin module, membrane-bound NAD(P) hydrolase, contains N-terminal PAAR domain |
| 59 | 78 | COG6044 | U | Type VI secretion system amidase effector protein Tae4 |
| 27 | 49 | COG6045 | U | Type VI secretion system amidase immunity protein Tai4 |
| 38 | 146 | COG6046 | U | Type VI secretion system immunity protein TsiV |
| 29 | 31 | COG6047 | U | Type VI secretion system transmembrane protein TssN |
| 24 | 31 | COG6048 | U | Type VI secretion system transmembrane protein TssO |
| 92 | 159 | COG6049 | U | ESX-1 (type VII) secretion system protein EccB |
| 87 | 87 | COG6050 | U | ESX-1 (type VII) secretion system protein EccE |
| 19 | 19 | COG6051 | U | ESX-1 (type VII) secretion system protein EssA/YueC |
| 11 | 38 | COG6052 | U | ESX-1 (type VII) secretion-associated protein EspE |
| 25 | 52 | COG6053 | U | ESX-1 (type VII) secretion-associated protein EspF |
| 35 | 208 | COG6054 | U | ESX-1 (type VII) secretion-associated protein EspG |
| 5 | 15 | COG6055 | U | ESX-1 (type VII) secretion-associated protein EspD/EspH |
| 5 | 10 | COG6056 | U | ESX-1 (type VII) secretion-associated protein EspJ |
| 4 | 10 | COG6057 | U | ESX-1 (type VII) secretion-associated protein EccK/EspK |
| 83 | 109 | COG6058 | U | Curli fimbriae curlin subunit, CsgA/CsgB family |
| 34 | 35 | COG6059 | U | Type VIII secretion (curli biogenesis) periplasmic factor CsgC |
| 89 | 92 | COG6060 | U | Type VIII secretion (curli biogenesis) periplasmic component CsgE |
| 111 | 117 | COG6061 | U | Type VIII secretion (curli biogenesis) assembly factor CsgF |
| 102 | 176 | COG6062 | U | ESX-1 (type VII) secretion system protein EccC |
| 157 | 160 | COG6063 | N U | Type IX secretion system/gliding motility periplasmic component PorK/GldK, forms PorK-PorN ring |
| 177 | 185 | COG6064 | N U | Type IX secretion system/gliding motility motor stator component PorL/GldL |
| 176 | 214 | COG6065 | N U | Type IX secretion system/gliding motility motor rotor component PorM/GldM |
| 176 | 204 | COG6066 | N U | Type IX secretion system/gliding motility periplasmic component PorN/GldN, forms PorK-PorN ring |
| 176 | 1194 | COG6067 | U | Outer membrane porin, includes type IX secretion system component PorP/SprF |
| 134 | 143 | COG6068 | U | Type IX secretion system outer membrane component PorQ |
| 205 | 1466 | COG6069 | U | Type IX secretion system outer membrane porin PorT/SprT, contains beta-barrel domain |
| 137 | 161 | COG6070 | U | Type IX secretion system sortase component PorU |
| 194 | 332 | COG6071 | U | Type IX secretion system outer membrane component PorV/LptO |
| 131 | 131 | COG6072 | U | Type IX secretion system component PorW/SprE, contains TPR repeats |
| 192 | 196 | COG6073 | U | Type IX secretion system outer membrane translocon component Sov/SprA |
| 176 | 176 | COG6074 | U | Type IX secretion system periplasmic plug component |
| 137 | 516 | COG6075 | U | Cell surface protein, contains SprB repeat of type IX secretion system |
| 440 | 476 | COG6076 | U | Response regulator PorX of type IX secretion system, combines REC and PglZ domains |
| 45 | 63 | COG6077 | U | Type X secretion system holin-like component ChiW |
| 429 | 565 | COG6078 | U | Peptidoglycan hydrolase, includes type X secretion system component ChiX |
| 17 | 23 | COG6079 | U | Type X secretion system inner membrane spanin ChiY, DUF2570 family |
| 24 | 29 | COG6080 | U | Type X secretion system outer membrane spanin ChiZ, Rz/Rz1 lysis system gene LysC |
| 49 | 57 | COG6081 | U | LydA family holin, phage or type X secretion system component |
| 223 | 9334 | COG6083 | U | Type IX system secreted protein, contains C-terminal sorting domain type A |
| 183 | 2187 | COG6085 | U | Type IX system secreted protein, contains C-terminal sorting domain type B |
| 27 | 46 | COG6086 | U | Type IX system secreted protein, contains C-terminal sorting domain type C |
| 312 | 328 | COG6088 | U | Membrane-anchored component of a predicted archaeal secretion system, contains flavodoxin-like domain, DUF4350 family |
| 21 | 22 | COG6091 | U | Crenarchaeal DNA import system 6TM protein CedA |
| 21 | 21 | COG6092 | U | Crenarchaeal DNA import system 2TM protein CedA1 |