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From Code to Creature
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; line-height: 13.0px; font: 10.0px Gotham} span.s1 {letter-spacing: -0.1px}A happenstance collaboration between biologists and roboticists led to the birth of a strange creation: living machines derived from frog stem cells.
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Ectopic eyes outside the head in Xenopus tadpoles provide sensory data for light-mediated learning
A major roadblock in the biomedical treatment of human sensory disorders, including blindness, has been an incomplete understanding of the nervous system and its ability …
Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
The major goal of regenerative medicine is to repair damaged tissues and organ systems, thereby restoring their native functions in the host. Control of innervation by re …
A scalable pipeline for designing reconfigurable organisms
Living systems are more robust, diverse, complex, and supportive of human life than any technology yet created. However, our ability to create novel lifeforms is currentl …
A cellular platform for the development of synthetic living machines
Robot swarms have, to date, been constructed from artificial materials. Motile biological constructs have been created from muscle cells grown on precisely shaped scaffol …
Kinematic self-replication in reconfigurable organisms
All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also …
Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells
Fundamental knowledge gaps exist about the plasticity of cells from adult soma and the potential diversity of body shape and behavior in living constructs derived from ge …
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A Leap Towards Building Synthetic Organisms
Douglas Blackiston’s frog-fueled research seeks to push the boundaries of understanding developing organisms.
Cells Form Into Living ‘Xenobots’ on Their Own
Embryonic cells can self-assemble into new forms that don’t resemble the bodies they usually generate, challenging old ideas of what defines an organism.
When Scientists Collaborate, Science Progresses
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; line-height: 13.0px; font: 10.0px Gotham} span.s1 {letter-spacing: 0.1px}Behind every successful scientist, there is another scientist.
Cellular Competence: Making Recombinant DNA Accessible
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Gotham; min-height: 14.0px} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; line-height: 10.1px; font: 10.0px Gotham; color: #6c6e70} span.s1 {font: 12.0px Gotham; color: #000000} Coaxing bacteria into taking up recombinant DNA was arduous until Douglas Hanahan took action.
Opinion: Interdisciplinary Approach Needed to Crack Morphogenesis
Physicists, geneticists, computer scientists, and biologists are working together to gain a full appreciation of the intricacies of organismal growth and form.