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Engineered Rabies Virus Illuminates Neural Circuitry
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; line-height: 13.0px; font: 10.0px Gotham} span.s1 {letter-spacing: -0.1px}Scientists turned a deadly virus into a crucial tool for understanding the wiring of the brain.
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PubMed articles
Transneuronal transfer of herpes virus from peripheral nerves to cortex and brainstem
The transneuronal transfer of neurotropic viruses may represent an effective tool for tracing chains of connected neurons because replication of virus in the recipient ne …
Macro-architecture of basal ganglia loops with the cerebral cortex: use of rabies virus to reveal multisynaptic circuits
We have used retrograde transneuronal transport of rabies virus to examine basal ganglia connections with the cerebral cortex. We injected rabies into the primary motor c …
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus
We report the development of a pseudorabies virus that can be used for retrograde tracing from selected neurons. This virus encodes a green fluorescent protein marker and …
Budding of rabies virus particles in the absence of the spike glycoprotein
Budding of enveloped viruses from cellular membranes is believed to de pend on the presence of transmembrane spike proteins interacting with cytoplasmic virus components. …
Spread and pathogenic characteristics of a G-deficient rabies virus recombinant: an in vitro and in vivo study
Rabies virus (RV), a highly neurotropic enveloped virus, is known to spread within the CNS by means of axonal transport. Although the envelope spike glycoprotein (G) of c …
Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons
There has never been a wholesale way of identifying neurons that are monosynaptically connected either to some other cell group or, especially, to a single cell. The best …
Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus
We describe a powerful system for revealing the direct monosynaptic inputs to specific cell types in Cre-expressing transgenic mice through the use of Cre-dependent helpe …
Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses
Rabies-virus-based monosynaptic tracing is a widely used technique for mapping neural circuitry, but its cytotoxicity has confined it primarily to anatomical applications …
Ascertaining cells' synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries
Brain function depends on synaptic connections between specific neuron types, yet systematic descriptions of synaptic networks and their molecular properties are not read …
A cross-disorder connectome landscape of brain dysconnectivity
Many human brain disorders are associated with characteristic alterations in the structural and functional connectivity of the brain. In this article, we explore how comm …
New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits
Glycoprotein-deleted (ΔG) rabies virus is a powerful tool for studies of neural circuit structure. Here, we describe the development and demonstrate the utility of new re …
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