T cell anergy induction regulation by Egr-2 and Egr-3 (MG-U74A)
Summary:
Analysis of pooled mRNA (2, 4, 6 hours) from A.E7 T cell clones activated in conditions that promote (anti-TCR) or inhibit (anti-TCR + CsA or PKCi or Combo) anergy induction. Results identify the early growth response gene 2 (Egr-2) and Egr-3 as key positive regulators of T cell anergy induction.
GPL81:
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Citation:
Safford M, Collins S, Lutz MA, Allen A et al. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol 2005 May;6(5):472-80. PMID: 15834410
