SIR2 knockout effect on virulence gene family silencing and activation
Summary:
Expression profiling of 3D7 silent information regulator 2 homolog (Sir2) knockout at ring stage, 8 hours post-invasion. Results identify Sir2-mediated, reversible heterochromatin silencing as one tier of epigenetic regulation of the antigenic variation var gene family.
Duraisingh MT, Voss TS, Marty AJ, Duffy MF et al. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell 2005 Apr 8;121(1):13-24. PMID: 15820675
