Toxicants effect on liver: pooled and individual sample comparison
Summary:
Analysis of livers of Sprague-Dawley males at various time points up to 168 hours after treatment with clofibrate, diethylhexylphthalate, or valproic acid. Expression profiles from pooled and individual samples compared. Results provide insight into the impact of pooling on experimental analysis.
Jolly RA, Goldstein KM, Wei T, Gao H et al. Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants. Physiol Genomics 2005 Aug 11;22(3):346-55. PMID: 15914576
