Analysis of tumor suppressor protein p53 gene dosage effects in HCT116 colorectal carcinoma-derived cell lines p53 -/-, +/- and +/+ at 0 and 12 hours. Cells with different numbers of functional TP53 alleles can be distinguished by gene expression profile.
GPL80:
[Hu6800] Affymetrix Human Full Length HuGeneFL Array
Citation:
Yoon H, Liyanarachchi S, Wright FA, Davuluri R et al. Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15632-7. PMID: 12438652
