Antitumor agent azinomycin B cellular effect: dose response
Summary:
Analysis of cells following treatment with 10 or 100 ug/ml of azinomycin B, a naturally occurring antitumor agent that forms interstrand crosslinks within the major groove of DNA. Results indicate that azinomycin B alters the expression of genes associated with DNA damage and repair.
Kelly GT, Liu C, Smith R 3rd, Coleman RS et al. Cellular effects induced by the antitumor agent azinomycin B. Chem Biol 2006 May;13(5):485-92. PMID: 16720269