Analysis of two-cell stage embryos maternally depleted for BRG1, a catalytic subunit of SWI/SNF-related chromatin remodeling complexes. After fertilization, the embryo shifts from maternal to zygotic genome expression. Results provide insight into the role of Brg1 in this transition.
Bultman SJ, Gebuhr TC, Pan H, Svoboda P et al. Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev 2006 Jul 1;20(13):1744-54. PMID: 16818606