Lung response to cigarette smoke: dose response and time course (PIQOR)
Summary:
Analysis of lungs of animals exposed to 300 or 600 ug total particulate matter (TPM)/l of cigarette smoke (CS) for up to 13 weeks and allowed to recover 2, 6, or 20 hours after the last exposure. Results provide insight into mechanisms involved in the onset and development of CS-related diseases.
Gebel S, Gerstmayer B, Kuhl P, Borlak J et al. The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression. Toxicol Sci 2006 Oct;93(2):422-31. PMID: 16870687
