Analysis of nutrient-limited continuous-culture cells at 12 25-minute intervals for 3 cycles. Cells grown under such conditions exhibit robust, periodic cycles in the form of respiratory bursts. Results provide insight into molecular mechanisms responsible for controlling metabolic oscillations.
Tu BP, Kudlicki A, Rowicka M, McKnight SL. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Science 2005 Nov 18;310(5751):1152-8. PMID: 16254148