Triterpenoid celastrol treatment and heat shock comparison
Summary:
Analysis of wild type cells treated with 10 uM of the triterpenoid celastrol for 1 hour or subjected to heat shock at 39 degrees C for 30 minutes. Celestrol is a small molecule that activates the human heat shock transcription factor HSF1.
GPL4226:
UT Southwestern Saccharomyces cerevisiae Spotted ORF 7k Array
Citation:
Trott A, West JD, Klaić L, Westerheide SD et al. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell 2008 Mar;19(3):1104-12. PMID: 18199679