Reticulocyte binding-like homolog 2b knockout effect on 3D7 parasites
Summary:
Analysis of reticulocyte binding-like homolog 2b (PfRh2b) null mutant 3D7 parasites. D10 isolate naturally lacks PfRh2b. Silencing of PfRh2b, a key invasion ligand, leads to altered invasion receptor dependency. Results provide insight into the molecular basis for invasion via an alternate pathway.
Baum J, Maier AG, Good RT, Simpson KM et al. Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions. PLoS Pathog 2005 Dec;1(4):e37. PMID: 16362075
