Erythropoietin effect on early erythroid progenitor cells
Summary:
Analysis of CD34+ erythroid progenitors stimulated with erythropoietin (Epo) with or without LY294002, a PI3K inhibitor. Epo promotes differentiation and proliferation of early progenitors via activation of PI3K. Results provide insight into molecular mechanisms underlying the effects of Epo.
Sivertsen EA, Hystad ME, Gutzkow KB, Døsen G et al. PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells. Br J Haematol 2006 Oct;135(1):117-28. PMID: 16965383