Anti-cancer agent sapphyrin PCI-2050 effect on lung cancer cell line: dose response
Summary:
Analysis of A549 lung cancer cells following treatment with anti-cancer agent sapphyrin PCI-2050 or transcription inhibitor actinomycin D. Hydrophilic sapphyrins localize to tumors, generate oxidative stress, and inhibit gene expression.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Wang Z, Lecane PS, Thiemann P, Fan Q et al. Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression. Mol Cancer 2007 Jan 19;6:9. PMID: 17233922
