Nrf2-deficient type II lung epithelial cell response to antioxidant supplementation
Summary:
Analysis of Nrf2 deficient lung epithelial cells treated with the antioxidant glutathione (GSH). GSH rescues cells from prooxidant-induced lung injury associated with Nrf2 deficiency. Results provide insight into the molecular mechanisms by which Nrf2 regulates cellular protection and proliferation.
Reddy NM, Kleeberger SR, Yamamoto M, Kensler TW et al. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics 2007 Dec 19;32(1):74-81. PMID: 17895394
