Tsc2 tumor suppressor gene mutant kidney response to genotoxic and non-genotoxic carcinogens: time course
Summary:
Analysis of kidneys of Eker males treated for up to 14 days with the genotoxic carcinogen aristolochic acid (AA) or the non-genotoxic carcinogen ochratoxin A (OTA). The Eker rat, heterozygous mutant for the tuberous sclerosis 2 (Tsc2) tumor suppressor gene, is a model to study renal carcinogenesis.
GPL341:
[RAE230A] Affymetrix Rat Expression 230A Array
Citation:
Stemmer K, Ellinger-Ziegelbauer H, Ahr HJ, Dietrich DR. Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis. Cancer Res 2007 May 1;67(9):4052-68. PMID: 17483316
