Analysis of mutant larvae defective for uroporphyrinogen decarboxylase (UROD) at 56 to 96 hours post-fertilization (hpf). UROD is the fifth enzyme in heme biosynthesis. The UROD mutant is a model for hepatoerythropoietic porphyria (HEP). Results provide insight into the pathogenesis of HEP.
Wang H, Zhou Q, Kesinger JW, Norris C et al. Heme regulates exocrine peptidase precursor genes in zebrafish. Exp Biol Med (Maywood) 2007 Oct;232(9):1170-80. PMID: 17895525
