Keloid fibroblast response to hydrocortisone in vitro
Summary:
Analysis of keloid fibroblasts (FBs) treated with 1.5uM hydrocortisone (HC). Keloids are benign dermal tumors that form during protracted wound healing. HC at 1.5uM inhibits collagen and elastin synthesis in normal scar FBs but not in keloid FBs. Results provide insight into keloid pathogenesis.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Smith JC, Boone BE, Opalenik SR, Williams SM et al. Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. J Invest Dermatol 2008 May;128(5):1298-310. PMID: 17989729
