Analysis of not1-2 spt3 double mutant cells. NOT1 encodes the scaffold subunit of the Ccr4-Not transcription factor complex. SPT3 encodes a transcription factor. The temperature sensitive not1-2 mutant exhibits transcriptional defects that are suppressed by the deletion of SPT3.
James N, Landrieux E, Collart MA. A SAGA-independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-not complex in Saccharomyces cerevisiae. Genetics 2007 Sep;177(1):123-35. PMID: 17660549