Transcription factor Ctip2 deficiency effect on brain striata
Summary:
Analysis of brain striata from neonates lacking the transcription factor Ctip2. Ctip2 is expressed by striatal medium spiny neurons (MSN), which are critical in motor control and selectively lost in Huntington's disease. Results provide insight into the role of Ctip2 in MSN differentiation.
Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y et al. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci 2008 Jan 16;28(3):622-32. PMID: 18199763
