Lung metastatic breast cancer cell line response to metadherin depletion
Summary:
Analysis of LM2 breast cancer cells depleted for metadherin (MTDH), a cell surface protein in breast tumors that mediates lung metastasis. LM2 cells were grown alone or on a monolayer of lung microvascular endothelial cells. Results provide insight into molecular mechanisms underlying MTDH action.
GPL4133:
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Citation:
Hu G, Chong RA, Yang Q, Wei Y et al. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 2009 Jan 6;15(1):9-20. PMID: 19111877
