LIM homeobox Lhx8 deficiency effect on newborn ovaries
Summary:
Wild type newborn ovary RNA was compared to newborn ovary RNA from Lhx8 deficient (-/-) or Nobox deficient (-/-) mice. Results indicate that Lxh8 is a critical factor for maintenance and differentiation of ooyctes during early embryogenesis and it acts in part by down-regulating the Nobox pathway.
Choi Y, Ballow DJ, Xin Y, Rajkovic A. Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival. Biol Reprod 2008 Sep;79(3):442-9. PMID: 18509161
