DataSet Record GDS3330: Expression Profiles Data Analysis Tools Sample Subsets
Title: Methotrexate-resistant HT29 colon adenocarcinoma cell line
Cluster AnalysisGDS3330 Cluster Image
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Summary: Analysis of HT29 colon cancer cells sensitive or resistant to methotrexate (MTX). MTX is used in the treatment of cancer. Chemotherapy effectiveness in cancer cells is compromised by development of drug resistance. Results provide insight into molecular mechanisms associated with drug resistance.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
  • Selga E, Morales C, Noé V, Peinado MA et al. Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics 2008 Aug 11;1:35. PMID: 18694510
  • Selga E, Oleaga C, Ramírez S, de Almagro MC et al. Networking of differentially expressed genes in human cancer cells resistant to methotrexate. Genome Med 2009 Sep 4;1(9):83. PMID: 19732436
  • Mencia N, Selga E, Noé V, Ciudad CJ. Underexpression of miR-224 in methotrexate resistant human colon cancer cells. Biochem Pharmacol 2011 Dec 1;82(11):1572-82. PMID: 21864507
Reference Series: GSE11440 Sample count: 6
Value type: count Series published: 2008/09/08