Curcumin effect on oxidatively stressed monocyte cell line: time course
Summary:
Analysis of U937 monoctyes exposed to oxidative stress then treated for 4 or 18 hrs with curcumin, a dietary polyphenol. Curcumin restores oxidative stress impaired histone deacetylase-2 activity and corticosteroid efficacy in vitro. Results provide insight into the molecular basis of these effects.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK et al. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol 2008 Sep;39(3):312-23. PMID: 18421014
