Oncogenic NRAS depletion effect on melanoma cell lines: time course
Summary:
Analysis of melanoma 224 and BL cells for up to 3 days after suppression of the mutant NRAS Q61R gene with siRNA siMut10 or siMut12. Activating mutations in NRAS gene is a common genetic event in malignant melanoma. Results provide insight into the role of NRAS in the pathogenesis of melanoma.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Eskandarpour M, Huang F, Reeves KA, Clark E et al. Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro. Int J Cancer 2009 Jan 1;124(1):16-26. PMID: 18814281
