DataSet Record GDS3721: Expression Profiles Data Analysis Tools Sample Subsets
Title: Pretreatment breast needle biopsies of locally advanced breast cancer
Cluster AnalysisGDS3721 Cluster Image
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Summary: Analysis of pretreatment breast cancer (BC) tumors from patients enrolled in a paclitaxel/radiation clinical trial. Patients achieved pathologic complete response (pCR) or partial response (pPR). Results provide insight into molecular markers of pathologic response to paclitaxel/RT treatment of BC.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
  • Bauer JA, Chakravarthy AB, Rosenbluth JM, Mi D et al. Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Clin Cancer Res 2010 Jan 15;16(2):681-90. PMID: 20068102
  • Lehmann BD, Bauer JA, Chen X, Sanders ME et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011 Jul;121(7):2750-67. PMID: 21633166
  • Adams S, Chakravarthy AB, Donach M, Spicer D et al. Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival. Breast Cancer Res Treat 2010 Dec;124(3):723-32. PMID: 20878462
Reference Series: GSE22513 Sample count: 28
Value type: transformed count Series published: 2010/06/23