Analysis of PlagL2-transduced, p53-null neural stem cells (NSCs) following differentiation induction. PLAGL2 strongly suppresses NSC differentiation while promoting self-renewal capacity. Results provide insight into the molecular basis of this differentiation-suppressive activity.
Zheng H, Ying H, Wiedemeyer R, Yan H et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 2010 May 18;17(5):497-509. PMID: 20478531