Analysis of Hoxa9-ER, an AML cell line created by transducing bone marrow with Hoxa9 fused to a modified ER ligand binding domain in the presence of tamoxifen (4-OHT), for up to 5 days post 4-OHT withdrawal which induces differentiation. Results provide insight into role of Hoxa9 in hematopoiesis.
Muntean AG, Tan J, Sitwala K, Huang Y et al. The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 2010 Jun 15;17(6):609-21. PMID: 20541477