Analysis of islet of Langerhans isolated from type 2 diabetic (T2D) organ donors. Phosphoinositide 3-kinases (PI3Ks) are critical regulators of pancreatic β cell mass and survival. Results provide insight into a role for class II PI3Ks in insulin secretion in pancreatic β cells.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Dominguez V, Raimondi C, Somanath S, Bugliani M et al. Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. J Biol Chem 2011 Feb 11;286(6):4216-25. PMID: 21127054
