Induced pluripotent stem cell-derived neurons from schizophrenia patients
Summary:
Analysis of induced pluripotent stem cells (iPSCs) generated from schizophrenic patients and differentiated to iPSC-derived neurons in vitro. Schizophrenic iPSC-derived neurons showed diminished neuronal connectivity. Results provide insight into molecular mechanisms responsible for schizophrenia.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011 May 12;473(7346):221-5. PMID: 21490598