Glycogen synthase kinase 3 inhibitor effect on MLL leukemia cells
Summary:
Analysis of MLL leukemia cell line RS4.11 treated with GSK-3 inhibitor SB216763 for 20 hours. Results provide insight into the molecular mechanisms underlying MLL leukemia dependence on GSK-3.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Wang Z, Iwasaki M, Ficara F, Lin C et al. GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell 2010 Jun 15;17(6):597-608. PMID: 20541704