TGFβ1 effect on HMEC-TR mammary epithelial cell line deficient in Smad4 or TIF1γ
Summary:
Analysis of HMEC-TR cells silenced for TIF1γ or Smad4 and treated with TGFβ. A strong EMT increase was observed in TIF1γ-silenced cells after TGFβ1 treatment; Smad4 inactivation completely blocked this process. Results show the relationship between TIF1γ and Smad4 in TGF-β signaling and EMT.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Hesling C, Fattet L, Teyre G, Jury D et al. Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells. EMBO Rep 2011 Jul 1;12(7):665-72. PMID: 21597466
