Inactivation of wt-p53 function in hTERT immortalized prostate epithelial EP156T cells: time course
Summary:
Temporal analysis of EP156T cells infected with a recombinant retrovirus encoding either p53R175H mutant (M cells), dominant-negative p53 peptide GSE56 (G cells) or control vector (C cells). Results provide insight into molecular mechanisms underlying early stages of transformation.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citations:
Tabach Y, Kogan-Sakin I, Buganim Y, Solomon H et al. Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer. PLoS One 2011 Jan 31;6(1):e14632. PMID: 21297939
Kogan-Sakin I, Tabach Y, Buganim Y, Molchadsky A et al. Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ 2011 Feb;18(2):271-81. PMID: 20689556
