Model for inflammatory signaling in prostate epithelium based on expression of a constitutively active version of IκB kinase 2 (IKK2ca)
Summary:
Analysis of prostate epithelium (PE)-PTEN+/-IKK2ca/ca and PE-PTEN+/- lateral prostates. PE-PTEN+/-IKK2ca prostates exhibit loss of smooth muscle but fail to induce invasiveness. Results provide insight into the molecular mechanism of inflammation and tumor development in the transgenic prostates.
Birbach A, Eisenbarth D, Kozakowski N, Ladenhauf E et al. Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model. Neoplasia 2011 Aug;13(8):692-703. PMID: 21847361
