Endoplasmic reticulum stress effect on lymphoblastoid cells of unrelated individuals
Summary:
Analysis of immortalized B cells from 60 unrelated individuals (grandparents in the HapMap CEPH-Utah pedigrees) treated in vitro with tunicamycin to induce ER stress. ER stress induces the unfolded protein response (UPR). Results provide insight into molecular mechanisms underlying UPR response.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Dombroski BA, Nayak RR, Ewens KG, Ankener W et al. Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells. Am J Hum Genet 2010 May 14;86(5):719-29. PMID: 20398888
