DataSet Record GDS4145: Expression Profiles Data Analysis Tools Sample Subsets
Title: Subcutaneous Interferon-beta-1b treatment in relapsing-remitting multiple sclerosis (U133 A): peripheral mononuclear blood cells
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Summary: Temporal analysis of PBMCs collected from 25 German relapsing-remitting multiple sclerosis patients treated with recombinant interferon-beta-1b (rIFN-β-1b, 250 µg every other day) for 2 years. Results provide insight into molecular mechanisms of IFN-b action.
Organism: Homo sapiens
Platform: GPL96: [HG-U133A] Affymetrix Human Genome U133A Array
Citations:
  • Goertsches RH, Hecker M, Koczan D, Serrano-Fernandez P et al. Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS. Pharmacogenomics 2010 Feb;11(2):147-61. PMID: 20136355
  • Hundeshagen A, Hecker M, Paap BK, Angerstein C et al. Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevance. J Neuroinflammation 2012 Jun 22;9:140. PMID: 22727118
  • Hecker M, Paap BK, Goertsches RH, Kandulski O et al. Reassessment of blood gene expression markers for the prognosis of relapsing-remitting multiple sclerosis. PLoS One 2011;6(12):e29648. PMID: 22216338
Reference Series: GSE24427 Sample count: 125
Value type: count Series published: 2010/09/29