Analysis of induced dopaminergic (iDA) neurons generated from E14.5 mouse embryonic fibroblasts (MEFs) reprogrammed by infection with lentiviruses expressing dopaminergic transcription factors Ascl1, Lmx1a and Nurr1. Results provide insight into the molecular basis of MEF to iDA reprogramming.
Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011 Jul 3;476(7359):224-7. PMID: 21725324