Analysis of ovaries from Swiss neonates cultured in media containing xenobiotics: 4-vinylcyclohexene diepoxide, methoxychlor, menadione. Non-renewing follicles are vulnerable to xenobiotic insult. Results provide insight into molecular mechanisms underlying xenobiotic-induced preantral ovotoxicity.
Sobinoff AP, Pye V, Nixon B, Roman SD et al. Adding insult to injury: effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility. Toxicol Sci 2010 Dec;118(2):653-66. PMID: 20829426
