Analysis of T cell acute lymphoblastic leukemia (T-ALL) cell lines treated with a peptide that inhibits the activity of IKK, an activator of NF-kB. NF-kB pathway is downstream of oncogenic Notch1 in T-ALL. Results provide insight into the molecular basis of Notch-induced NF-kB activation in T-ALL.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Espinosa L, Cathelin S, D'Altri T, Trimarchi T et al. The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. Cancer Cell 2010 Sep 14;18(3):268-81. PMID: 20832754
