Polycomb histone methyltransferase Ezh2-deficient hearts: right ventricle and interventricular septum
Summary:
Analysis of right ventricle and interventricular septum from Ezh2-deficient adults. Loss of Ezh2 leads to cardiac hypertrophy and fibrosis. Results provide insight into the role of Ezh2 in postnatal organ homeostasis.
Delgado-Olguín P, Huang Y, Li X, Christodoulou D et al. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet 2012 Jan 22;44(3):343-7. PMID: 22267199
