Vesicular acetylcholine transporter knockdown effect on heart
Summary:
Analysis of heart from vesicular acetylcholine transporter (VAChT)-deficient C57BL/6 males. The VAChT KD animals have a systemic decrease in ACh release and cardiac dysfunction. Results provide insight into potential molecular changes in the heart induced by decreased cholinergic neurotransmission.
Roy A, Lara A, Guimarães D, Pires R et al. An analysis of the myocardial transcriptome in a mouse model of cardiac dysfunction with decreased cholinergic neurotransmission. PLoS One 2012;7(6):e39997. PMID: 22768193