Ts65Dn aneuploidy model of Down syndrome: skeletal muscle
Summary:
Analysis of soleus muscle, in the basal state, from five-month-old Ts65Dn Down syndrome (DS) males. Ts65Dn DS model exhibits muscle weakness in vivo. Results provide insight into the molecular mechanisms underlying DS-associated muscle dysfunction.
Cowley PM, Keslacy S, Middleton FA, DeRuisseau LR et al. Functional and biochemical characterization of soleus muscle in Down syndrome mice: insight into the muscle dysfunction seen in the human condition. Am J Physiol Regul Integr Comp Physiol 2012 Dec 15;303(12):R1251-60. PMID: 23115123
