Notch1 signaling inhibition effect on aortic valve interstitial cells
Summary:
Analysis of aortic valve interstitial cells treated with the Notch1 signaling inhibitor DAPT. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification. Results provide insight into the role of Notch in the pathogenesis of calcific aortic valve disease.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Acharya A, Hans CP, Koenig SN, Nichols HA et al. Inhibitory role of Notch1 in calcific aortic valve disease. PLoS One 2011;6(11):e27743. PMID: 22110751
