HdhQ111 knock-in model of Huntington's disease: striatum and cerebellum
Summary:
Analysis of striatum and cerebellum from a HdhQ111/111 knock-in model of Huntington's disease (HD). The 10-week HdhQ111/111 mice exhibit somatic instability in striatum but not in cerebellum. Results provide insight into the molecular basis of tissue-specific somatic instability.
Lee JM, Zhang J, Su AI, Walker JR et al. A novel approach to investigate tissue-specific trinucleotide repeat instability. BMC Syst Biol 2010 Mar 19;4:29. PMID: 20302627
