Analysis of primary abdominal neuroblastoma (NB) tumors from a metastatic NB model. This model recapitulates two alterations frequent observed in metastatic NB: MYCN overexpression and loss of caspase-8 expression. Results provide insight into the molecular mechanisms underlying metastatic NB.
Teitz T, Inoue M, Valentine MB, Zhu K et al. Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis. Cancer Res 2013 Jul 1;73(13):4086-97. PMID: 23536557