NOD/SCID/huALL xenotransplant model of pediatric acute leukemia
Summary:
Analysis of xenograft leukemia samples from NOD/SCID mice transplanted with leukemia cells from patients with pediatric BCP-ALL. The xenograft samples displayed short or long “Time To Leukemia” (TTL). Results provide insight into molecular mechanisms underlying the distinct TTL phenotypes.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Meyer LH, Eckhoff SM, Queudeville M, Kraus JM et al. Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways. Cancer Cell 2011 Feb 15;19(2):206-17. PMID: 21295523
