Retinoic acid deficiency effect on embryonic brain
Summary:
Analysis of anterior and posterior brain regions from Retinaldehyde Dehydrogenase 2 null-mutant (Raldh2-/-) embryos, which are unable to synthesize retinoic acid (RA) from maternally-derived retinol. Results provide insight into the repertoire of RA-regulated genes in the developing embryo.
Paschaki M, Schneider C, Rhinn M, Thibault-Carpentier C et al. Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. PLoS One 2013;8(4):e62274. PMID: 23638021