HIV envelope protein gp120 effect on activated B cells from healthy donors: time course
Summary:
Temporal analysis of B cells isolated from healthy donors in response to activation in the presence of HIV-1 envelope protein gp120 with high (gp120++) or low (gp120-) affinity for integrin α4β7. Results provide insight into mechanisms by which α4β7-gp120 interaction negatively affects B cells.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Jelicic K, Cimbro R, Nawaz F, Huang da W et al. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression. Nat Immunol 2013 Dec;14(12):1256-65. PMID: 24162774
