Histone deacetylase 3 deficiency effect on the heart
Summary:
Analysis of hearts of 6 week old mutants deleted for histone deacetylase 3 (HDAC3). HDAC3 deletion occurred 7 days after birth. These MCH3-KO mutants are viable on normal chow but a high fat diet is lethal. The results underscore the impact gene-diet interactions may have on cardiovascular health.
Sun Z, Singh N, Mullican SE, Everett LJ et al. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem 2011 Sep 23;286(38):33301-9. PMID: 21808063
